Genome
Read every variant: health risk, pharmacogenomics, polygenic scores, phenotype prediction, and more.
A weighted sum of thousands of common variants that summarises inherited disposition for a complex trait. We explain how it is built, what the number means, and where it falls short.
APOE has three common alleles (ε2, ε3, ε4) and the ε4 allele is the strongest known common-variant risk factor for late-onset Alzheimer's. Here is what your genotype means and why we resolve it in four tiers.
Star alleles, metabolizer status, and the ten FDA Black Box drug-gene alerts Haeckel surfaces. Concrete examples from CYP2D6 codeine and DPYD fluorouracil.
How HIrisPlex-S predicts pigmentation from a small SNP panel, why height prediction works better in some ancestries than others, and what to make of disagreements with the mirror.
The Genome surface holds seventeen analytical modules. This article explains what sits in each tab, what number to look at first, and which numbers are safe to ignore.